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Seek medical advice if you: cannot keep fluids down are urinating much less than normal feel severely weak or dizzy experience persistent vomiting or diarrhoea develop signs of significant dehydration Potentially serious complications can include: acute pancreatitis gallbladder problems severe gastrointestinal reactions dehydration-related kidney injury serious allergic reactions low blood sugar when combined with insulin or certain diabetes medicines worsening diabetic retinopathy in susceptible patients sudden or rapidly worsening vision problems The MHRA advises patients to seek urgent medical help for severe, persistent abdominal pain that may spread to the back, as this can be a sign of acute pancreatitis